The aim of this study was to prepare Spherical crystals of Lactose monohydrate by Solvent change method (SCM) with Distilled Water-Ethanol-Ethyl Acetate System. The prepared crystals were evaluated for flowability, compressibility. Blend were prepared by using lactose crystals and poorly flowing API�s i.e. Paracetamol, Furosemide to check retention of flow property by replacing with poorly flowing APIs. Tablets were prepared by direct compression technique then evaluated for tensile strength, weight variation, hardness, friability, disintegration time. The prepared crystals were white, free flowing and spherical in shape. The yield of spherical crystals was 75%. Prepared crystals were also improved in compressibility and flowability. The tablet dosage form prepared from crystals showed better hardness, friability, disintegration time. The study revealed that this is a simple method and can be adopted in an academic lab for conversion of lactose to directly compressible form. The shift in tablet technique opened new arenas for excipients industries. In such demanding situation spherical crystallization proves better technique.
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